Cagrilintide Powder

Umthengisi weCagrilintide Powder 98% High-purity Peptide Raw Materials

I-YTBIO inikezela ngeCagrilintide ecocekileyo kakhulu (98%), eyenziwe phantsi kwenkqubo yokulawula umgangatho engqongqo ukuqinisekisa ubunyulu bemveliso, uzinzo, kunye nokuhambelana kwayo yonke into.

Yintoni iCagrilintide?

I-Cagrilintide Powder yi-analogue ye-amylin esebenza ixesha elide efakwa ngaphantsi kwesikhumba kube kanye ngeveki. I-Canaglitide ixelisa i-amylin, i-hormone eveliswa yi-pancreas kwaye ikhutshwa zii-pancreatic beta cells kunye ne-insulin emva kokutya. Ibandakanyeka kulawulo lokugcwala ngomsebenzi engqondweni kwaye iphucula ulawulo lwe-glycemic ngokulibazisa ukukhupha isisu kunye nokuthintela ukukhutshwa kwe-glucagon.

I-Cagrilintide inciphisa ukuthathwa kwamandla kwaye ilawula ukhetho lokutya kunye nokukhetha; inefuthe elilawula i-glucose ngokukhupha kunye ne-insulin, ithintela ukukhululwa kwe-glucagon emva kokutya, kwaye ilibazise ukukhupha isisu. Inika iingenelo ezibalulekileyo kunyango lwesifo seswekile, ukutyeba kakhulu, isifo se-metabolic, kunye nesifo sentliziyo, inika amathuba amaninzi okusetyenziswa kwezonyango.

Kutheni Khetha i-YTBIO?

I-YTBIO iseke inkqubo yolawulo lomgangatho oluqinileyo lweepeptides, isebenzisa ulawulo olupheleleyo phezu kobunyulu, ukungcola, kunye nokuhambelana kwebhetshi ukuhlangabezana neemfuno zakho zezinto eziluhlaza ezikumgangatho ophezulu.

Sisebenzisa iindlela zokulawula umgangatho ezifana ne-HPLC ukuqinisekisa ubunyulu kunye nozinzo lwemveliso.

Iinkcukacha zemveliso, iZatifikethi zoHlalutyo (i-COA), kunye namaxwebhu obuchwephesha afanelekileyo ayafumaneka xa eceliwe.

Sineziqinisekiso ezininzi zamazwe ngamazwe, kuquka i-cGMP, i-ISO9001, i-ISO22000, i-FSSC22000, i-BRC, i-Kosher, kunye ne-Halal.

Ngamava eminyaka eli-12 kushishino kunye nendawo yethu yokuvelisa engama-10,000-square-meter, sinikezela ngeenkonzo ezizinzileyo zemveliso kubathengi kwihlabathi liphela.

Ingxelo uvavanyo

Imisebenzi ephambili yePhysical

1. Management Weight

Inciphisa umnqweno wokutya kwaye inciphise ukutya

Ilibazisa ukuphelelwa sisisu kwaye yandisa ixesha lokuziva unelisekile

Ikhuthaza ibhalansi yamandla angalunganga kwaye iququzelela imetabolism yamafutha

2. Ukulawulwa kweGlucose yegazi

Ithintela ukukhutshwa kwe-glucagon kakhulu, ithintela ukunyuka okukhulu kweglucose egazini emva kokutya

Isebenza ngokubambisana ne-insulin ukuphucula i-glucose homeostasis

Iphucula kakhulu amanqanaba e-glycated hemoglobin (HbA1c) kwizigulane ezinesifo seswekile sohlobo lwesibini

3. Ukungenelela kwiMetabolic Syndrome

Izifundo zeklinikhi zibonisa iindlela zokuphucuka kweempawu zemetabolism ezifana noxinzelelo lwegazi kunye ne-lipids yegazi

Inceda ekunciphiseni umngcipheko weengxaki ezinxulumene nokutyeba kakhulu

Iimvavanyo kwiCagrilintide

Ukutyeba sisifo esingapheliyo esifuna unyango lwexesha elide. Yandisa umngcipheko wohlobo lwe-2 yeswekile, uxinzelelo lwegazi, kunye nesifo se-cardiovascular, okanye ikhokelela kuluhlu lweengxaki, ezichaphazela ixesha lokuphila kunye nokunciphisa umgangatho wobomi. Kubantu abatyebileyo okanye abatyebileyo, ukungenelela kwendlela yokuphila yonyango olukhethiweyo, kodwa ezinye izigulane azikwazi ukufezekisa iinjongo ezilindelekileyo zokulahlekelwa kwesisindo ngenxa yezizathu ezahlukahlukeneyo kwaye zifuna ukunciphisa umzimba ngoncedo lwamachiza.

Okwangoku, i-GLP-1 receptor agonists ezifana ne-liraglutide kunye ne-semaglutide zivunyiwe yi-US FDA kunyango lwezigulane ezithile ezityebileyo. I-GLP-1 yihomoni ekhutshwa ziiseli zamathumbu. Ukongeza ekukhuthazeni ukukhuselwa kwe-insulin kunye nokuthintela ukukhutshwa kweglucagon ukukhuthaza imetabolism yeswekile yegazi, inokulibazisa ukukhupha isisu kunye nokucinezela ukutya.

Ukongeza kwindlela yokubonisa i-GLP-1, abaphandi bazama ukulinganisa iziphumo zezinye iihomoni ezinxulumene nendlala kunye nokuhlutha. Enye yazo yi-amylin, ihomoni evuselela ukuhlutha. I-Cagrilintide yi-analogue yokuqala ye-amylin yexesha elide efundelwe ukulawula ubunzima. Yintoni ukusebenza kwayo kunye nokhuseleko?

Kutshanje, uNjingalwazi uDavid CW Lau kunye neqela lakhe elivela kwiCumming School of Medicine kwiYunivesithi yaseCalgary eCanada bapapashe inqaku eliphambili kwijenali yezonyango iLancet, enika ingxelo ngokusebenza kwangaphambili kunye nokunyamezeleka kokhuseleko lwe-cagrilintide kulawulo lobunzima bobunzima kunye nokutyeba. abantu.

Iziphumo zibonise ukuba njenge-adjunct kwi-lifestyle intervention, i-injection kanye ngeveki yonyango ye-cagrilintide inokunciphisa ubunzima obuphakathi ukuya kwi-11.5 kg emva kweeveki ze-26, kwaye ikhuselekile kwaye iyanyamezeleka, ekulindeleke ukuba inike isisombululo esitsha sokunciphisa umzimba. unyango.

Uphononongo luyi-multicenter, i-randomized, i-double-blind, i-placebo-elawulwayo kunye ne-positive-controlled, i-dose-finding Phase 2 yovavanyo oluqhutywe kumaziko ophando lwe-57 kumazwe e-10 kuquka iCanada, iJapan, i-United Kingdom kunye ne-United States. Izifundo ziye zahlangabezana nale nqobo ilandelayo:

• Ubudala ≥ iminyaka eyi-18, akukho seswekile;
• Isalathisi sobunzima bomzimba (BMI) ≥ 30kg / m2; okanye BMI ≥ 27kg / m2, kunye noxinzelelo lwegazi okanye dyslipidemia.

Ukusukela nge-1 kaMatshi ukuya nge-19 ka-Agasti 2019, uphononongo luquke itotali yezifundo ezingama-706, eziye zabelwa ngokungenamkhethe kwiqela leziyobisi okanye kwiqela le-placebo kumlinganiselo we-6:1:

• I-injection subcutaneous ye-cagrilintide kanye ngeveki, ihlukaniswe ngamaqela e-5 dose (0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg): abantu abayi-100-102 kwiqela ngalinye;
• Isitofu esingaphantsi kwe-liraglutide 3.0mg kanye ngosuku: abantu abangama-99;
• Iqela le-placebo elihambelana nedosi: abantu abali-101.

Uphononongo lwahlala kwiiveki ze-32, kunye nexesha le-26-iveki yonyango (kubandakanywa ne-6-iveki yokunyuka kwe-dose) kunye ne-6-iveki yokulandelelana ngaphandle kwonyango.
Isiphelo esiphambili sophando sasiyipesenti yokuguqulwa kwesisindo somzimba ukusuka kwisiseko ukuya kwiveki ye-26, kwaye umphumo wonyango uhlolwe kubo bonke abathathi-nxaxheba abangahleliwe. Ukhuseleko lwavavanywa kubo bonke abathathi-nxaxheba abafumene ubuncinane idosi enye yonyango olungahleliwe.

Ikhuselekile kwaye Iyasebenza Ekulawuleni Ubunzima Bexesha Elide Kubantu Abanobunzima Obugqithisileyo Okanye Abatyebe Kakhulu

Ubunzima bokutshintsha liqela lonyango: Izigulana ezininzi kwiqela le-cagrilintide 4.5 mg (mfusa) zilahlekelwe ngaphezulu kwe-5%, i-10%, kunye ne-15% yobunzima bomzimba wabo xa kuthelekiswa ne-liraglutide (ebomvu)

• Ukuyeka ngokusisigxina unyango (n=73 [10%]) kwenzeka kumazinga afanayo kuwo onke amaqela onyango, ngokuyintloko ngenxa yeziganeko ezimbi (n=30 [4%]). Bebonke ngabathathi-nxaxheba abangama-29 (4%) barhoxa kulingo.
• Ngokusekelwe kuvavanyo lweyeza lolingo (kucingelwa ukuba bonke abathathi-nxaxheba babambelele kunyango kulo lonke uvavanyo), intsingiselo yepesenti yokulahlekelwa kwesisindo yayinkulu kuzo zonke iidosi ze-cagrilintide (0.3 mg-4.5 mg, 6.0% -10.8% [6.4 kg -11.5 kg]) xa kuthelekiswa ne indawo ye-placebo (3.0% [3.3 kg]). Abathathi-nxaxheba kwiqela le-cagrilintide 4.5 mg nabo balahlekelwa ubunzima obuninzi kunabo bakwiqela le-liraglutide 3.0 mg (10.8% [11.5 kg] vs 9.0% [9.6 kg]).
• Iziphumo ezifanayo zokulahlekelwa kwesisindo zabonwa ngokusekelwe kuvavanyo lwesicwangciso sonyango (kungakhathaliseki ukuba ngaba abathathi-nxaxheba baphazamise okanye bahoxisiwe kunyango).
• Ngokubhekiselele kukhuseleko, iziganeko ezixhaphakileyo ezixhaphakileyo yayikukungasebenzi kakuhle kwesisu (njengesicaphucaphu, ukuqunjelwa, kunye norhudo) kunye nokusabela kwendawo yolawulo. Xa kuthelekiswa neqela le-placebo, umlinganiselo wabathathi-nxaxheba abafake i-cagrilintide i-0.3 mg-4.5 mg bafumana iziganeko ezimbi zesisu rhoqo (41% -63% vs 32%), ikakhulukazi isicaphucaphu (20% -47% vs 18%).

Uphononongo lubonise ukuba unyango lwe-cagrilintide lunokunciphisa kakhulu ubunzima kwaye lunyamezeleke ngokugqithisileyo kunye nezigulane ezigqithiseleyo. Ngexesha elifanayo, iidosi ezahlukeneyo ze-cagrilintide zineempembelelo ezibalulekileyo kubunzima bomzimba. Iziphumo zolu vavanyo zibonelela ngesiseko senzululwazi sokuqhuba ngakumbi ulingo lweSigaba sesi-3. Kwixesha elizayo, uphando olunzulu lunokuqhutywa kwimiphumo yeedosi eziphezulu ze-cagrilintide.

Qhagamshelana nathi

I-Yuantai Organic Bio izibophelele ekuboneleleni abathengi ngeCagrilintide Powder ekumgangatho ophezulu eyi- 98% kunye neenkonzo ukuze wonke umthengi akwazi ukonwabela ukutya kwendalo, okunempilo, nokusemgangathweni ophezulu. Ukuba unemibuzo okanye iimfuno malunga neemveliso zethu, nceda uzive ukhululekile ukunxibelelana nathi, kwaye siya kukuphendula ngokukhawuleza.

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