Ngaba uyazi ukuba yintoni i-hesperidin?

Ⅰ, Intshayelelo yeHesperidin

hesperidin luhlobo lwezityalo zendalo ezizezodidi lweflavonoid. Ifumaneka kakhulu kumaxolo eziqhamo zesitrasi ezifana nexolo leorenji, ixolo lepomelo, kunye nexolo lelamuni. I-Hesperidin ine-antioxidant enamandla, i-anti-inflammatory, antibacterial, antiviral kunye neminye imisebenzi ye-biological, ngoko isetyenziswa ngokubanzi kumayeza, iimveliso zempilo, izimonyo kunye nezinye iinkalo. I-Hesperetin yenye yezinto ezisebenzayo ze-orange peel. Kuye kwaqinisekiswa ukuba isakhiwo sayo siyinxalenye ye-phenolic. Iipropati zayo ziikristale ezingenambala okanye i-crystalline powders enevumba elimnandi. Indawo yokunyibilika yi 50℃~51℃ kwaye indawo yokubila yi 232℃. Kulula ukuguquka kwaye kunzima ukunyibilika emanzini, ukunyibilika ngokulula kwizinyibilikisi eziphilayo ezifana ne-ethanol kunye ne-ether, kunempembelelo entle ekuphatheni amangolwane esilwanyana. iziphumo ebezingalindelekanga ezinetyhefu encinci, intsalela ephantsi, kwaye akukho lungcoliseko lokusingqongileyo. Kunyango lweklinikhi, lunobugwenxa beendleko eziphezulu kunye nobunzima bokwenza amalungiselelo alula ukuyisebenzisa. I-Tangeretin isetyenziswa kakhulu kwi-Chemicalbook organic chemistry kunye nesayensi yobomi kunye nezinye iinkalo. Ngenxa yokuba umxholo we-tangeretin kwizityalo uphantsi kwaye uyabiza, uphando lwe-tangeretin kwilizwe lam lusemva. ilizwe lam lityebile kwimithombo yesitrasi kwaye linethemba elibanzi lokukhutshwa kunye nokusetyenziswa kwe-tangeretin.

Ⅱ, Indlela yokutsalwa kweHesperidin

hesperidin ithathwa ikakhulu kwizityalo ze-Rutaceae okanye iintsapho ze-Euphorbiaceae. Iindlela zokukhupha ziquka i-recrystallization, ikholamu yechromatography, i-high-speed countercurrent chromatography kunye ne-carbon dioxide supercritical extraction. Indlela yokubuyisela kwakhona: I-Dancy orange luhlobo oludumileyo lwesitrasi oluzalelwa eUnited States. Uphando lufumanise ukuba ioyile e-orenji ecinezelekileyo eyenziwe nge-orenji ye-Danxi yenza i-precipitate emthubi emva kwe-centrifugation kunye nokukhenkceza kwexesha elide. I-Limonene yaphinda yasuswa yaza yaphinda yaqaqambisa ukufumana i-tangeretin emhlophe ekristale. I-Tangeretin idityaniswe kunye neoli ye-tangerine ecinezelekileyo njengemveliso yemveliso, enokunciphisa kakhulu iindleko zayo zokuvelisa. Ikholamu yechromatography: Ikholamu yechromatography isebenzisa i-gradient elution kunye nezinyibilikisi ezixubeneyo zendalo ukukhupha i-tangeretin kwizityalo ezinjengeorenji eswiti, iCitrus aurantium, i-orenji yeDanxi kunye neCroton enoboya begqabi. I-high-speed counter-current chromatography: I-high-speed counter-current chromatography, (i-HSCCC ngokufutshane) bubuchwephesha bekhromatografi yokusasazwa kolwelo. Xa kuthelekiswa nezinye iindlela zokwahlula i-chromatographic, i-HSCCC ayisebenzisi nayiphi na i-Chemicalbook carrier eqinileyo okanye inkxaso njengenqanaba elimileyo. Isampulu ifezekisa kuphela ukwahlula okusebenzayo kunye nokulungiswa kweemveliso ezicocekileyo ngexesha elifutshane ngokuhlukana kokusabalalisa phakathi kwezigaba ezibini ze-solvents immiscible. Kwiminyaka yakutshanje, Ifumene ingqalelo kunye nesicelo kwintsimi yokukhupha iimveliso zendalo. Indlela yokutsalwa kwekharbhon dayoksayidi: Ikharbon diokside eyingozi inefuthe elikhethekileyo lokunyibilika kwiimveliso ezithile zendalo. Umgaqo we-carbon dioxide supercritical extraction technology kukusebenzisa ubudlelwane phakathi kwe-solubility ye-supercritical carbon dioxide kunye nobuninzi bayo, oko kukuthi, ukusebenzisa uxinzelelo kunye nobushushu ukuze kuqinisekiswe ukunyibilika kwekharbon diokside. Impembelelo yokutsalwa. Kwimeko ye-supercritical, i-supercritical carbon dioxide idityaniswa nezinto eziza kwahlulwa, ukuze amacandelo e-polarities ahlukeneyo, amanqaku abilayo kunye nobunzima beemolekyuli athathwe ngokukhetha ngokulandelelana, emva koko ulwelo oluphezulu lunokuguqulwa lube lulwelo oluqhelekileyo. ukunciphisa uxinzelelo, ukwanda kweqondo lokushisa, njl.

Ⅲ, Indima kaHesperidin

1. Isiphumo se-Antioxidant

I-Tangerine inefuthe elinamandla lokulwa ne-antioxidant, inokukhupha ii-radicals zamahhala, ukunciphisa ukusabela koxinzelelo lwe-oxidative, kwaye ikhusele iiseli kumonakalo owenziwe nge-oxidative. Uphando lubonisa ukuba i-tangeretin inokunciphisa umngcipheko wesifo senhliziyo, umhlaza kunye nezinye izifo kunye nokulibazisa inkqubo yokuguga.

2. Impembelelo echasayo

I-Hesperidin inokuthintela impendulo yokuvuvukala kunye nokunciphisa iimpawu ezivuthayo. Uphando lubonisa ukuba i-tangeretin inokunciphisa ukubonakaliswa kwezinto ezivuthayo, inqanda ukusebenza kweeseli ezivuthayo, kunye nokunciphisa ukukhululwa kwabalamli abavuthayo.

3. Impembelelo ye-Antibacterial

I-Hesperidin inefuthe elinamandla lokulwa ne-antibacterial kwaye inokuthintela ukukhula kunye nokuzala kweebhaktheriya ezahlukeneyo. Uphando lubonisa ukuba i-tangeretin inokuthintela ukukhula kwe-Staphylococcus aureus, i-Escherichia coli, i-Streptococcus kunye nezinye iibhaktheriya ze-pathogenic.

4. Impembelelo ye-Antiviral

I-Tangerine inokuthintela ukukhula kunye nokuzala kweentsholongwane ezahlukeneyo, kuquka i-virus yomkhuhlane, i-virus ye-hepatitis B, njl.

Ⅳ,Isiphumo se-tangeretin

1. Iilipids ezisezantsi zegazi

I-Hesperetin inokunciphisa i-serum ye-cholesterol epheleleyo, i-triglycerides kunye ne-low-density lipoprotein amanqanaba e-cholesterol kwaye inyuse amanqanaba aphezulu e-lipoprotein ye-cholesterol, ngaloo ndlela inciphisa umngcipheko wesifo senhliziyo.

2. Ukulwa umhlaza

I-Tangerine inokuthintela ukukhula kunye nokuveliswa kweeseli zomhlaza kwaye ikhuthaze i-apoptosis yeeseli ze-tumor, ngaloo ndlela ibe nemiphumo yokuchasana nomhlaza. Uphononongo lubonise ukuba i-tangeretin ineziphumo ezibalulekileyo ezithintelayo kwiintlobo zomhlaza ezahlukeneyo ezinjengomhlaza webala, umhlaza wemiphunga, kunye nomhlaza wamabele.

3. Khusela isibindi

I-Tangerine inokunciphisa umonakalo wesibindi kwaye ikhuthaze ukuvuselelwa kunye nokulungiswa kweeseli zesibindi, ngaloo ndlela ikhusela isibindi. Uphononongo lubonise ukuba i-tangeretin inokunciphisa impendulo yoxinzelelo lwe-oxidative yesibindi kunye nokunciphisa iqondo lomonakalo wesibindi.

4. I-Anti-diabetes

I-Hesperetin ineempawu ezichasene nesifo seswekile ngokunciphisa amanqanaba eswekile yegazi kunye nokuphucula ukuvakalelwa kwe-insulin. Uphando lubonisa ukuba i-tangeretin inokunciphisa ukufunxwa kunye nokusetyenziswa kweglucose kwaye ikhuthaze ukukhuselwa kunye nokusetyenziswa kwe-insulin.

Ⅴ, Ukusetyenziswa kweHesperidin

1.Icandelo lezamayeza

I-Hesperetin isetyenziswa ngokubanzi kwicandelo lezonyango njengeyeza elincedisayo lonyango kwizifo ezahlukeneyo ezifana ne-antioxidant, i-anti-inflammatory, antibacterial, kunye ne-antiviral. Ngokomzekelo, i-tangeretin inokunciphisa umngcipheko wesifo senhliziyo, umhlaza, isifo seswekile kunye nezinye izifo kunye nokukhuthaza ukubuyiswa kwesigulane.

2. Intsimi yeemveliso zokhathalelo lwempilo

I-Hesperetin isetyenziswa ngokubanzi kwimveliso yokhathalelo lwempilo njengeyona nto iphambili kwiimveliso zokhathalelo lwempilo. Ngokomzekelo, i-tangeretin inokulibazisa ukuguga, iphucule ukungakhuseleki, ikhuthaze ukulala, njl., kwaye ibe yenye yeemveliso zezempilo ezisetyenziswa ngokuqhelekileyo kubantu banamhlanje.

3. Ibala lezithambiso

I-Hesperetin isetyenziswa ngokubanzi kwintsimi yezithambiso njengeyona nto iphambili kwizinto zokuthambisa. Umzekelo, i-tangeretin ineziphumo ezininzi ezifana ne-antioxidant, i-anti-inflammatory, antibacterial, kunye ne-antiviral, kwaye ibe yenye yezinto ezibalulekileyo kwizinto zokuthambisa.

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